Cell Mediated and Humoral Immune responses to Mumps Virus: Recent Developments

Mahon, Bernard P. and Flynn, Marion A. (2003) Cell Mediated and Humoral Immune responses to Mumps Virus: Recent Developments. Recent Research Developments in Virology, 5. pp. 97-115.

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Despite the extensive use of Mumps virus vaccines for almost forty years, there is still a paucity of knowledge concerning the Host-Pathogen Interaction. This paper reviews the advances in our knowledge of the antiviral immune response with particular reference to the selection of attenuated mumps virus strains used in different vaccine formulations. The ability of mumps viruses to evade the interferon component of the immune response is described in detail. This study also presents recent findings from our laboratory and others concerning the humoral and cell mediated responses to mumps virus. Particular attention is placed on mumps virus induction of interleukin-10 (IL-10) and the potential for this to be a novel immune evasion strategy is discussed. Finally, recent advances in our understanding of the immune response to mumps virus are placed in the broader context of our current understanding of this disease.

Item Type: Article
Keywords: Cell mediated; humoral immune responses; mumps; virus;
Academic Unit: Faculty of Science and Engineering > Biology
Faculty of Science and Engineering > Research Institutes > Institute of Immunology
Item ID: 156
Depositing User: Bernard Mahon
Date Deposited: 16 Dec 2004
Journal or Publication Title: Recent Research Developments in Virology
Refereed: Yes

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