Ex Vivo Cytokine responses against Parvovirus B19 Antigens in previously infected pregnant women


Mahon, Bernard P. and Corcoran, Amanda and McParland, Peter and Davoren, Anne and Doyle, Sean (2003) Ex Vivo Cytokine responses against Parvovirus B19 Antigens in previously infected pregnant women. Journal of Medial Virology, 70 (3). pp. 475-480. ISSN 0146-6615

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Abstract

Parvovirus B19 infection is a significant cause of fetal death. The aim of this study was to investigate the role of maternal immune status in modulating susceptibility to fetal B19 infection. Peripheral blood was obtained from pregnant women (n = 199) with no clinical evidence of recent B19 infection. Evaluation of ex vivo T cell responses from 149/199 individuals showed significantly higher interferon-gamma levels for seropositive individuals following VP1 (268 +/- 36 versus 103 +/- 19 pg/ml; P = 0.003) and VP2 (242 +/- 42 versus 91 +/- 16 pg/ml; P = 0.01) antigen stimulation. Significantly higher levels of interleukin-2 were also observed in seropositive individuals following both VP1 (P = 0.0003) and VP2 (P = 0.0005) stimulation. The observed Th1 cellular response is lower than that documented previously for non-pregnant individuals and strongly suggests that diminution of the maternal anti-viral immune response may increase susceptibility to fetal B19 infection.

Item Type: Article
Keywords: pregnancy; cellular immunity; erythrovirus; interferon-y;
Academic Unit: Faculty of Science and Engineering > Biology
Faculty of Science and Engineering > Research Institutes > Institute of Immunology
Item ID: 158
Identification Number: 10.1002/jmv.10420
Depositing User: Bernard Mahon
Date Deposited: 16 Dec 2004
Journal or Publication Title: Journal of Medial Virology
Publisher: Wiley-Liss
Refereed: Yes
URI:

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