An in-silico analysis of the SMART study of HIV infection

Ferreira, Jorge and Middleton, Rick (2008) An in-silico analysis of the SMART study of HIV infection. In: 7th IFAC Symposium on Modelling and Control, November 2008.

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A mathematical model is developed to further examine the dynamic interaction of uninfected T cells with Human Immunodeficiency Virus (HIV) mutations. We study how the dynamics are affected by immune response to infected cells under intermittent antiretroviral therapy. Our goal is to analyze the SMART (Strategies for Management of Anti-RetroviralTherapy) study outcomes and based on that try to identify possible causes of its failure. We mathematically describe the HIV infection and perform numerical simulation to approach the course of the disease. Preliminary results suggest that the scheduling of follow-up visits and working range of CD4+ T cells count used during the SMART study could explain the observed adverse outcomes in that trial.

Item Type: Conference or Workshop Item (Paper)
Keywords: Modelling and simulation; Biomedical systems; Control theory; HIV dynamics; Hamilton Institute.
Academic Unit: Faculty of Science and Engineering > Biology
Faculty of Science and Engineering > Research Institutes > Hamilton Institute
Item ID: 1666
Depositing User: Hamilton Editor
Date Deposited: 17 Nov 2009 10:04
Refereed: Yes

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