Oyarzun, Diego and Ingalls, Brian and Kalamatianos, Dimitrios
Optimal metabolic regulation by temporal variation of enzyme activities: a control theoretic approach.
Proceedings of the Foundations of Systems Biology in Engineering Conference, Stuttgart, Germany. FOSBE 2007 .
In this paper we use an optimal control approach to analyze time dependent enzyme concentrations that minimize the transition time of a metabolic pathway while respecting the natural constraints imposed by a limited biosynthetical capacity. Our main result states that, under appropriate assumptions, at each time instant all the available enzyme production capacity is allocated to a single reaction, a finding reminiscent of bang-bang control laws typical in classical time-optimal control.
||Metabolic pathways; metabolic regulation; optimal control;
||Faculty of Science and Engineering > Research Institutes > Hamilton Institute
||22 Sep 2010 15:26
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||Proceedings of the Foundations of Systems Biology in Engineering Conference, Stuttgart, Germany. FOSBE 2007
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