Hendy, Gillian M.
Polypyrrole modified with sulfonated beta-cyclodextrin: Controlled release of DA and host-guest complexation properties.
PhD thesis, National University of Ireland Maynooth.
This thesis originates with the synthesis and characterisation of conducting polypyrrole [PPy] films, deposited in the presence of various electroytes, predominantly, a large anionic cyclodextrin [SB-CD]. The presence of the SB-CD dopant was confirmed using SEM/EDAX. It was shown that the SB-CD-doped PPy films have cation exchange properties and the oxidation and reduction of the polymer is accompanied by solvent, H20, exchange. Once characterised, these materials were used for the incorporation and release of an important pharmaceutical compound, dopamine [DA]. It was found that the sulfonated beta-cyclodextrin [SB-CD] dopant enhanced the delivery of the DA by - 90%, in comparison to a PPy film doped with sulfate. It was demonstrated that the thickness of the SB-CD-doped PPy, as well as the application of appropriate incorporation and release potentials were the most important factors controlling the release profiles. The electrical stimulation applied during release of the drug was a significant factor and in comparison to diffusion, the rate of release of DA was increaded by - 80% on the application of an oxidation stilumus. These promising results lead to an investigation into the host-guest complexation propertirs of the SB-CD with DA.
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