Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation


Singh, Ishwar and Vyle, Joseph S. and Heaney, Frances (2009) Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation. Chemical Communications (22). pp. 3276-3278. ISSN 1359-7345

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Abstract

Solid-phase oligonucleotide conjugation by nitrile oxide–alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.

Item Type: Article
Additional Information: © Royal Society of Chemistry 2009
Keywords: copper-free click chemistry; solid-phase; oligonucleotide conjugation; catalyst;
Academic Unit: Faculty of Science and Engineering > Chemistry
Item ID: 2706
Identification Number: DOI: 10.1039/B904185K
Depositing User: Dr. Frances Heaney
Date Deposited: 14 Sep 2011 13:53
Journal or Publication Title: Chemical Communications
Publisher: Royal Society of Chemstry
Refereed: Yes
URI:

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