BMP4 induces an epithelial–mesenchymal transition-like response in adult airway epithelial cells

Molloy, Emer L. and Adams, Aine and Moore, J. Bernadette and Masterson, Joanne C. and Madrigal-Estebas, Laura and Mahon, Bernard P. and O'Dea, Shirley (2008) BMP4 induces an epithelial–mesenchymal transition-like response in adult airway epithelial cells. Growth Factors, 26 (1). pp. 12-22. ISSN 0897-7194

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Bone morphogenetic proteins (BMPs) are critical morphogens and play key roles in epithelial–mesenchymal transitions (EMTs) during embryogenesis. BMP4 is required for early mesoderm formation and also regulates morphogenesis and epithelial cell differentiation in developing lungs. While, BMP signalling pathways are activated during lung inflammation in adult mice, the role of BMPs in adult lungs remains unclear.We hypothesised that BMPs are involved in remodelling processes in adult lungs and investigated effects of BMP4 on airway epithelial cells. BEAS-2B cell growth decreased in the presence of BMP4. Cells acquired a mesenchymal-like morphology with downregulation of adherens junction proteins and increased cell motility. Changes in extracellular matrix-related gene expression occurred with BMP4 treatment including upregulation of collagens, fibronectin and tenascin C.We conclude that the activity of BMP4 in EMT during development is recapitulated in adult airway epithelial cells and suggest that this activity may contribute to inflammation and fibrosis in vivo.

Item Type: Article
Keywords: BMP; EMT; ECM; E-cadherin; airway;
Academic Unit: Faculty of Science and Engineering > Research Institutes > Institute of Immunology
Item ID: 2830
Identification Number: 10.1080/08977190801987166
Depositing User: Dr. Shirley O'Dea
Date Deposited: 15 Nov 2011 12:30
Journal or Publication Title: Growth Factors
Publisher: Informa Healthcare
Refereed: Yes

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