O'Loughlin, Aran and McGee, Mark and Waters, Sinead M. and Doyle, Sean and Earley, Bernadette
Examination of the bovine leukocyte
environment using immunogenetic biomarkers to
assess immunocompetence following exposure to
Veterinary Research, 7 (45).
The molecular mechanisms by which stress induces the development of pathologies remains
unclear, although it is recognised that one of the major factors affecting health as a consequence of stress is the
involvement of the neuroendocrine system. In cattle, a number of necessary husbandry practices have been shown
to activate the stress response, yet very little is known about the impact these have at the molecular level. The
objectives of the study were to characterise, in male and female beef calves, the immune response to weaning
stress in bovine leukocytes at the physiological and molecular levels and to assess the difference between calves
weaned in the presence of the dam and those weaned and penned away from the dam.
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