Synthesis, X-ray crystal structure, anti-fungal and anti-cancer activity of [Ag2(NH3)2(salH)2] (salH2 ¼salicylic acid)

McCann, Malachy and Coyle, Barry and Kavanagh, Kevin and McKee, Vickie and Kayal, Nijhuma and Egan, Denise and Deegan, Carol Deegan and Finn, Gregory J. and Devereux, Michael (2004) Synthesis, X-ray crystal structure, anti-fungal and anti-cancer activity of [Ag2(NH3)2(salH)2] (salH2 ¼salicylic acid). Journal of Inorganic Biochemistry, 98 (8). pp. 1361-1366. ISSN 0162-0134

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[Ag2(NH3)2(salH)2] (salH2 ¼salicylic acid) was synthesised from salicylic acid and Ag2O in concentrated aqueous NH3 and the dimeric Ag(I) complex was characterised using X-ray crystallography. The complex is centrosymmetric with each metal coordinated to a salicylate carboxylate oxygen and to an ammonia nitrogen atom in an almost linear fashion. The two [Ag(NH3)(salH)] units in the complex are linked by an Ag–Ag bond. Whilst metal-free salH2 did not prevent the growth of the fungal pathogen Candida albicans [Ag2(NH3)2(salH)2], [Ag2(salH)2] and some simple Ag(I) salts greatly inhibited cell reproduction. SalH2, [Ag2(NH3)2(salH)2] [Ag2(salH)2] and AgClO4 produced a dose-dependent cytotoxic response against the three human derived cancer cell lines, Cal-27, Hep-G2 and A-498, with the Ag(I)-containing reagents being the most effective.

Item Type: Article
Keywords: Silver(I); Salicylate; X-ray structure; Anti-fungal; Anti-cancer;
Academic Unit: Faculty of Science and Engineering > Chemistry
Item ID: 306
Identification Number: 10.1016/j.jinorgbio.2004.04.016
Depositing User: Dr. Kevin Kavanagh
Date Deposited: 01 Oct 2007
Journal or Publication Title: Journal of Inorganic Biochemistry
Publisher: Elsevier
Refereed: Yes

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