McCann, Malachy and Coyle, Barry and Kavanagh, Kevin and McKee, Vickie and Kayal, Nijhuma and Egan, Denise and Deegan, Carol Deegan and Finn, Gregory J. and Devereux, Michael
Synthesis, X-ray crystal structure, anti-fungal and anti-cancer activity of [Ag2(NH3)2(salH)2] (salH2 Â¼salicylic acid).
Journal of Inorganic Biochemistry, 98.
[Ag2(NH3)2(salH)2] (salH2 Â¼salicylic acid) was synthesised from salicylic acid and Ag2O in concentrated aqueous NH3 and the
dimeric Ag(I) complex was characterised using X-ray crystallography. The complex is centrosymmetric with each metal coordinated
to a salicylate carboxylate oxygen and to an ammonia nitrogen atom in an almost linear fashion. The two [Ag(NH3)(salH)] units in
the complex are linked by an Ag-Ag bond. Whilst metal-free salH2 did not prevent the growth of the fungal pathogen Candida albicans [Ag2(NH3)2(salH)2], [Ag2(salH)2] and some simple Ag(I) salts greatly inhibited cell reproduction. SalH2,[Ag2(NH3)2(salH)2] [Ag2(salH)2] and AgClO4 produced a dose-dependent cytotoxic response against the three human derived cancer cell lines, Cal-27, Hep-G2 and A-498, with the Ag(I)-containing reagents being the most effective.
2004 Elsevier Inc. All rights reserved.
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