Kavanagh, Kevin and Reeves, Emer P.
Exploiting the potential of Insects for in vivo
pathogenicity testing of Microbial pathogen.
FEMS Microbiology Reviews, 28.
Conventional assays for quantifying the virulence of microbial pathogens and
mutants have traditionally relied upon the use of a range of mammalian species. A
number of workers have demonstrated that insects can be used for evaluating microbial
pathogenicity and provide results comparable to those that can be obtained with
mammals since one component of the vertebrate immune system, the innate immune
response, remains similar to that found in insects. Larvae of the Greater Wax Moth Galleria mellonella have been used to evaluate the virulence of a range of bacterial and
fungal pathogens and a correlation with the virulence of these microbes in mice has been established. This review highlights the similarities of the vertebrate and insect innate immune responses to infection and identifies the potential use of insects for the in vivo evaluation of the microbial pathogenicity.
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