Distinct subpopulations of gy T cells are present in normal and tumor-bearing human liv

Kenna, Tony and Golden-Mason, Lucy and Norris, Suzanne and Hegarty, John E. and O'Farrelly, Cliona and Doherty, Derek G. (2004) Distinct subpopulations of gy T cells are present in normal and tumor-bearing human liv. Clinical Immunology, 113 (1). pp. 56-63.

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gy T cells are thought to mediate immune responses at epithelial surfaces. We have quantified and characterized hepatic and peripheral blood gy T cells from 11 normal and 13 unresolved tumor-bearing human liver specimens. gy T cells are enriched in normal liver (6.6% of T cells) relative to matched blood (0.9%; P = 0.008). The majority express CD4CD8 phenotypes and many express CD56 and/or CD161. In vitro, hepatic gy T cells can be induced to kill tumor cell lines and release interferon-g, tumor necrosis factor-a, interleukin-2 and interleukin- 4. Analysis of Vgand Vy chain usage indicated that Vy3+ cells are expanded in normal livers (21.2% of gy T cells) compared to blood (0.5%; P = 0.001). Tumor-bearing livers had significant expansions and depletions of gy T cell subsets but normal cytolytic activity. This study identifies novel populations of liver T cells that may play a role in immunity against tumors.

Item Type: Article
Keywords: Tumor immunity; Liver; Human; gy T cells; Cytokines; Cytotoxicity
Academic Unit: Faculty of Science and Engineering > Biology
Item ID: 327
Depositing User: Dr. Derek Doherty
Date Deposited: 23 Sep 2008
Journal or Publication Title: Clinical Immunology
Publisher: Elsevier
Refereed: Yes

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