Control structure and limitations of biochemical networks

Lopez-Caamal, F. and Oyarzun, D.A. and Moreno, J.A. and Kalamatianos, D. (2010) Control structure and limitations of biochemical networks. In: American Control Conference (ACC), 2010. IEEE, pp. 6668-6673. ISBN 9781424474257

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Biochemical networks typically exhibit intricate topologies that hinder their analysis with control-theoretic tools. In this work we present a systematic methodology for the identification of the control structure of a reaction network. The method is based on a bandwidth reduction technique applied to the incidence matrix of the network’s graph. In addition, in the case of mass-action and stable networks we show that it is possible to identify linear algebraic dependencies between the time-domain integrals of some species’ concentrations. We consider the extrinsic apoptosis pathway and an activation– inhibition mechanism to illustrate the application of our results

Item Type: Book Section
Additional Information: Preprint version of published paper. The definitive version of this paper is available at DOI: 10.1109/NICRSP.1996.542760
Keywords: activation-inhibition mechanism , bandwidth reduction technique; biochemical networks; control structure; extrinsic apoptosis pathway; incidence matrix; linear algebraic; time-domain integrals;
Academic Unit: Faculty of Science and Engineering > Research Institutes > Hamilton Institute
Item ID: 3633
Depositing User: Dimitris Kalamatianos
Date Deposited: 02 May 2012 15:29
Publisher: IEEE
Refereed: No

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