Staunton, Lisa and O’Connell, Kathleen and Ohlendieck, Kay
Proteomic Profiling of Mitochondrial
Enzymes during Skeletal Muscle Aging.
Journal of Aging Research (908035).
Mitochondria are of central importance for energy generation in skeletal muscles. Expression changes or functional alterations in
mitochondrial enzymes play a key role during myogenesis, fibre maturation, and various neuromuscular pathologies, as well as
natural fibre aging.Mass spectrometry-based proteomics suggests itself as a convenient large-scale and high-throughput approach
to catalogue the mitochondrial protein complement and determine global changes during health and disease. This paper gives a
brief overview of the relatively new field of mitochondrial proteomics and discusses the findings from recent proteomic surveys of
mitochondrial elements in aged skeletal muscles. Changes in the abundance, biochemical activity, subcellular localization, and/or
posttranslationalmodifications in key mitochondrial enzymes might be useful as novel biomarkers of aging. In the long term, this
may advance diagnostic procedures, improve the monitoring of disease progression, help in the testing of side effects due to new
drug regimes, and enhance our molecular understanding of age-related muscle degeneration.
||Copyright © 2011 Lisa Staunton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The original, definitive version of the article is available in the Journal of Aging Research, 2011, article ID 908035: doi:10.4061/2011/908035 . Research in the author’s laboratory was supported by grants
from Science Foundation Ireland, the European Commission,
the Irish Health Research Board, the Higher Education
Authority, and Muscular Dystrophy Ireland.
||Proteomic Profiling; Mitochondrial
Enzymes; Skeletal Muscle Aging; myogenesis; fibre maturation; neuromuscular pathologies;
||Science & Engineering > Biology
Prof. Kay Ohlendieck
||03 Jul 2012 16:04
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||Journal of Aging Research
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