Cotton, James A. and McInerney, James O.
Eukaryotic genes of archaebacterial origin are more
important than the more numerous eubacterial genes,
irrespective of function.
Proceedings of the National Academy of Sciences , 107 (40).
The traditional tree of life shows eukaryotes as a distinct lineage
of living things, but many studies have suggested that the first
eukaryotic cells were chimeric, descended from both Eubacteria
(through the mitochondrion) and Archaebacteria. Eukaryote nuclei
thus contain genes of both eubacterial and archaebacterial origins,
and these genes have different functions within eukaryotic cells.
Here we report that archaebacterium-derived genes are significantly
more likely to be essential to yeast viability, are more highly
expressed, and are significantly more highly connected and more
central in the yeast protein interaction network. These findings
hold irrespective of whether the genes have an informational or
operational function, so that many features of eukaryotic genes
with prokaryotic homologs can be explained by their origin, rather
than their function. Taken together, our results show that genes of
archaebacterial origin are in some senses more important to yeast
metabolism than genes of eubacterial origin. This importance
reflects these genes’ origin as the ancestral nuclear component of
the eukaryotic genome.
||The definitive version of this article is available at PNAS October 5, 2010 vol. 107 no. 40 17252-17255 doi: 10.1073/pnas.1000265107
||endosymbiosis; gene essentiality; eukaryote origin; protein interaction
||Faculty of Science and Engineering > Biology
Dr. James McInerney
||04 Jul 2012 15:25
|Journal or Publication Title:
||Proceedings of the National Academy of Sciences
||National Academy of Sciences
Repository Staff Only(login required)
||Item control page