Zimberlin, Jessica A. and McManus, Jennifer J. and Crosby, Alfred J.
Cavitation rheology of the vitreous: mechanical properties of biological tissue.
Soft Matter, 6.
We demonstrate the importance of measuring the mechanical properties of biological tissue in vivo by
quantifying the mechanical properties of bovine vitreous both in its native state and upon removal
from the eye. The mechanical properties are determined by the cavitation rheology technique
developed in our labs to determine the linear modulus. This technique involves inducing a cavitation
event at the tip of a syringe that is located at an arbitrary location within the vitreous sample. The
pressure at which the cavitation event occurs can be directly related to the modulus. We show that the
modulus decreases upon removal of the vitreous from the ocular cavity and decreases still further when
the vitreous cortex, the thin membrane that surrounds the vitreous, is removed. This study has
important implications for both diagnostic science of diseased tissue and developmental biology in
studying tissue properties with age.
||The definitive version of this article is available in Soft Matter Vol.6(2010) pp.3632-3635. DOI: 10.1039/B925407B
||Cavitation; rheology; vitreous; mechanical properties; biological tissue;
||Faculty of Science and Engineering > Chemistry
||29 Aug 2012 15:42
|Journal or Publication Title:
||Royal Society of Chemistry
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