Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation


Schroeder, Martina (2010) Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation. Biochemical Pharmacology, 79 (3). pp. 297-306. ISSN 0006-2952,

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Abstract

The human DEAD-box RNA helicase DDX3 has been implicated to play a role in the whole repertoire of processes regulating gene expression, including transcription, splicing, mRNA export and translation. It has also been suggested to be involved in cell cycle control and the regulation of apoptosis. In addition, DDX3 was recently shown to be part of innate immune signalling pathways and to contribute to the induction of anti-viral mediators, such as type I interferon. Interestingly, DDX3 appears to be a prime target for viral manipulation: at least four different viruses, namely Hepatitis C virus (HCV), Hepatitis B virus (HBV), Human Immunodeficiency Virus (HIV) and poxviruses, encode proteins that interact with DDX3 andmodulate its function. HIV and HCV seem to co-opt DDX3 and require it for their replication. It has therefore been suggested that DDX3 could be a novel target for the development of drugs against these two viruses, both of which still pose major global health threats. However, in the light of the apparent multifunctionality of DDX3 in the cell, drug development strategies targeting DDX3 will have to be carefully evaluated. This review summarises the available data on the cellular functions of DDX3 and discusses theirmanipulation by the different viruses known to target DDX3. Understanding the viral strategies for manipulating or co-opting DDX3 in functional and molecular detail can provide valuable insights for the development of strategies to therapeutically target DDX3.

Item Type: Article
Additional Information: The definitive version of this article is available at doi:10.1016/j.bcp.2009.08.032
Keywords: DEAD-box helicase; Gene expression regulation; Hepatitis virus; Viral immune evasion; Cell growth control; Type I interferon;
Academic Unit: Faculty of Science and Engineering > Biology
Item ID: 4230
Depositing User: Martina Schroeder
Date Deposited: 28 Feb 2013 09:49
Journal or Publication Title: Biochemical Pharmacology
Publisher: Elsevier
Refereed: Yes
URI:

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