Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry


Freeman, Colin and Vyle, Joseph S. and Heaney, Frances (2013) Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry. RSC Advances, 3. pp. 1652-1655. ISSN 2046-2069

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Abstract

Photoresponsive oligonucleotides (ONs) incorporating isoxazole-linked azobenzene (AB) moieties were prepared by resin-supported nitrile oxide-alkyne cycloaddition (NOAC) chemistry. The thermal and photochromic properties of the modified ONs were significantly influenced by the extent of π-conjugation between the isoxazole and the AB modules

Item Type: Article
Keywords: Oligo switches; photoresponsive oligonucleotide conjugates; solid-supported click chemistry;
Academic Unit: Faculty of Science and Engineering > Chemistry
Item ID: 4743
Identification Number: 10.1039/C2RA22815G
Depositing User: Dr. Frances Heaney
Date Deposited: 30 Jan 2014 12:06
Journal or Publication Title: RSC Advances
Publisher: Royal Society of Chemistry
Refereed: Yes
Funders: SFI (05/PICA/B838/NS), Irish Research Council of Science and Engineering (S/2007/48)
URI:

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