One Juliet and four Romeos: VeA and its methyltransferases


Sarikaya-Bayram, Ozlem and Palmer, Jonathan M. and Keller, Nancy and Braus, Gerhard H. and Bayram, Ozgur (2015) One Juliet and four Romeos: VeA and its methyltransferases. Frontiers in Microbiology, 6 (1). pp. 1-7. ISSN 1664-302X

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Abstract

Fungal secondary metabolism has become an important research topic with great biomedical and biotechnological value. In the postgenomic era, understanding the diversity and the molecular control of secondary metabolites (SMs) are two challenging tasks addressed by the research community. Discovery of the LaeA methyltransferase 10 years ago opened up a new horizon on the control of SM research when it was found that expression of many SM gene clusters is controlled by LaeA. While the molecular function of LaeA remains an enigma, discovery of the velvet family proteins as interaction partners further extended the role of the LaeA beyond secondary metabolism. The heterotrimeric VelB–VeA–LaeA complex plays important roles in development, sporulation, secondary metabolism, and pathogenicity. Recently, three other methyltransferases have been found to associate with the velvet complex, the LaeA-like methyltransferase F and the methyltransferase heterodimers VipC–VapB. Interaction of VeA with at least four methyltransferase proteins indicates a molecular hub function for VeA that questions: Is there a VeA supercomplex or is VeA part of a highly dynamic cellular control network with many different partners?

Item Type: Article
Additional Information: This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. We would like to thank Betim Karahoda (Maynooth University, Ireland) for critical reading of the manuscript. This publication has been supported in part by a research grant from Science Foundation Ireland (SFI) under Grant Number 13/CDA/2142 to Özgür Bayram, in part by National Institutes of Health Grant NIH R01 Al065728-01 to Nancy Keller and in part by the Deutsche Forschungsgemeinschaft (DFG) to Gerhard H. Braus. Özlem Sarikaya-Bayramhas been supported by the Irish Research Council (IRC) Postdoctoral Fellowship (GOIPD/2014/178).
Keywords: secondary metabolism; methyltransferases; velvet family; LaeA; VelB–VeA–LaeA; VosA; LlmF; VapA– VipC–VapB;
Academic Unit: Faculty of Science and Engineering > Biology
Item ID: 5969
Identification Number: 10.3389/fmicb.2015.00001
Depositing User: Ozgur Bayram
Date Deposited: 18 Mar 2015 16:26
Journal or Publication Title: Frontiers in Microbiology
Publisher: Frontiers
Refereed: Yes
Funders: Science Foundation Ireland (SFI), Irish Research Council (IRC)
URI:

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