The Aspergillus nidulans MAPK Module AnSte11-Ste50- Ste7-Fus3 Controls Development and Secondary Metabolism


Bayram, Ozgur and Bayram, Ozlem Sarikaya and Ahmed, Yasar Luqman and Maruyama, Jun-ichi and Valerius, Oliver and Rizzoli, Silvio O. and Ficner, Ralf and Irniger, Stefan and Braus, Gerhard H. (2012) The Aspergillus nidulans MAPK Module AnSte11-Ste50- Ste7-Fus3 Controls Development and Secondary Metabolism. PLos Genetics, 8 (7). e1002816. ISSN 1553-7390

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Abstract

The sexual Fus3 MAP kinase module of yeast is highly conserved in eukaryotes and transmits external signals from the plasma membrane to the nucleus. We show here that the module of the filamentous fungus Aspergillus nidulans (An) consists of the AnFus3 MAP kinase, the upstream kinases AnSte7 and AnSte11, and the AnSte50 adaptor. The fungal MAPK module controls the coordination of fungal development and secondary metabolite production. It lacks the membrane docking yeast Ste5 scaffold homolog; but, similar to yeast, the entire MAPK module’s proteins interact with each other at the plasma membrane. AnFus3 is the only subunit with the potential to enter the nucleus from the nuclear envelope. AnFus3 interacts with the conserved nuclear transcription factor AnSte12 to initiate sexual development and phosphorylates VeA, which is a major regulatory protein required for sexual development and coordinated secondary metabolite production. Our data suggest that not only Fus3, but even the entire MAPK module complex of four physically interacting proteins, can migrate from plasma membrane to nuclear envelope.

Item Type: Article
Additional Information: © 2012 Bayram et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Aspergillus nidulans; MAPK Module AnSte11-Ste50- Ste7-Fus3; Development; Secondary Metabolism;
Academic Unit: Faculty of Science and Engineering > Biology
Item ID: 6244
Identification Number: 10.1371/journal.pgen.1002816
Depositing User: Ozgur Bayram
Date Deposited: 13 Jul 2015 15:21
Journal or Publication Title: PLos Genetics
Publisher: Public Library of Science
Refereed: Yes
URI:

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