LaeA Control of Velvet Family Regulatory Proteins for Light-Dependent Development and Fungal Cell-Type Specificity


Bayram, Ozlem Sarikaya and Bayram, Ozgur and Valerius, Oliver and Park, Hee-Soo and Irniger, Stefan and Gerke, Jennifer and Ni, Min and Han, Kap-Hoon and Yu, Jae-Hyuk and Braus, Gerhard H. (2010) LaeA Control of Velvet Family Regulatory Proteins for Light-Dependent Development and Fungal Cell-Type Specificity. PLoS Genetics, 6 (12). e1001226. ISSN 1553-7390

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Abstract

VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual reproduction and secondary metabolism in Aspergillus nidulans. In the dark, VeA bridges VelB and LaeA to form the VelB-VeA-LaeA (velvet) complex. The VeA-like protein VelB is another developmental regulator, and LaeA has been known as global regulator of secondary metabolism. In this study, we show that VelB forms a second light-regulated developmental complex together with VosA, another member of the velvet family, which represses asexual development. LaeA plays a key role, not only in secondary metabolism, but also in directing formation of the VelB-VosA and VelB-VeA-LaeA complexes. LaeA controls VeA modification and protein levels and possesses additional developmental functions. The laeA null mutant results in constitutive sexual differentiation, indicating that LaeA plays a pivotal role in inhibiting sexual development in response to light. Moreover, the absence of LaeA results in the formation of significantly smaller fruiting bodies. This is due to the lack of a specific globose cell type (Hu¨ lle cells), which nurse the young fruiting body during development. This suggests that LaeA controls Hülle cells. In summary, LaeA plays a dynamic role in fungal morphological and chemical development, and it controls expression, interactions, and modification of the velvet regulators.

Item Type: Article
Additional Information: This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
Keywords: LaeA Control; Velvet Family; Regulatory Proteins; Light-Dependent; Development; Fungal Cell-Type Specificity;
Academic Unit: Faculty of Science and Engineering > Biology
Item ID: 6247
Identification Number: 10.1371/journal.pgen.1001226
Depositing User: Ozgur Bayram
Date Deposited: 14 Jul 2015 15:26
Journal or Publication Title: PLoS Genetics
Publisher: Public Library of Science
Refereed: Yes
URI:

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