The causes of protein evolutionary rate variation

McInerney, James O. (2006) The causes of protein evolutionary rate variation. Trends in Ecology and Evolution, 21 (5). pp. 230-232.

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The rate of protein evolution varies more than 1000-fold and, for the past 30 years, it was thought that the rate was determined by protein function. Drummond and co-workers have now shown that a single factor underlying mRNA expression, protein abundance and synonymous codon usage is the chief causal agent of protein evolutionary rate in yeast. It will be interesting to see whether this is shown to be a universal rule for all biological systems.

Item Type: Article
Keywords: Protein evolutionary rate, protein function
Academic Unit: Faculty of Science and Engineering > Biology
Item ID: 670
Depositing User: Dr. James McInerney
Date Deposited: 17 Aug 2007
Journal or Publication Title: Trends in Ecology and Evolution
Publisher: Elsevier
Refereed: Yes

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