Buggy, Carol Elizabeth
(2012)
The Synthesis of Glucosamine-Based
Derivatives with Potential as
Immunomodulators, Kinase Inhibitors,
and Prodrugs.
PhD thesis, National University of Ireland Maynooth.
Abstract
Chapter 1 gives a brief outline of the relevance of carbohydrates in biological systems. Special attention has been given to the roles of glucosamine and N-acetyl glucosamine.
Chapter 2 details the synthesis of novel glucosamine-based serine glycolipids, which were tested for their immunomodulatory ability. The experimental conditions investigated are discussed in detail.
Chapter 3 describes the synthesis of a glucosamine-based serine building block, and its incorporation into a series of glycopeptides, via SPPS techniques, with potential as a kinase inhibitor. The experimental conditions for the synthesis and purification of these peptides are discussed in detail.
Chapter 4 describes an investigation into the introduction of functionalities at the C-6 position of the sugar moiety, with the aim of synthesising an azido-functionalised glucosamine derivative. The experimental details of this investigation are described.
Chapter 5 describes the synthesis of a glucosamine-based dopamine derivative, which has potential as a dopamine prodrug. The various approaches taken in this synthesis, and the experimental conditions are discussed in detail.
Chapter 6 gives the experimental details and characterisations for the compounds reported throughout this thesis.
Chapter 7 contains appendices describing 1H NMR assignation, and also experimental details of attempted experiments.
Chapter 8 contains the bibliographic information used as references in this thesis.
| Item Type: |
Thesis
(PhD)
|
| Keywords: |
Glucosamine-Based Derivatives; Immunomodulators; Kinase Inhibitors; Prodrugs; |
| Academic Unit: |
Faculty of Science and Engineering > Chemistry |
| Item ID: |
6728 |
| Depositing User: |
IR eTheses
|
| Date Deposited: |
05 Jan 2016 16:40 |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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