Montagner, Diego and Marzano, Cristina and Gandin, Valentina (2011) Synthesis, characterization and cytotoxic activity of palladium (II) dithiocarbamate complexes with α,ω-diamines. Inorganica Chimica Acta, 376 (1). pp. 574-580. ISSN 0020-1693

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Abstract

The polymeric [PdCl(dithiocarbamate)]n complexes, in which the ligand ion is dimethyldithiocarbamate (DMDT), pyrrolidine dithiocarbamate (PyDT, (CH2)4NCS2−) and sarcosine ethyl ester dithiocarbamate (ESDT, EtO2CCH2N(CH3)CS2−), have been reacted with chelating diamines, like ethylenediamine (en) or 1,3-diaminopropane (dap) and long chain diamines, like 1,4-diaminobutane (dab) or 1,7-diaminoheptane (dah). The reaction products depend on either diamine chain length or molar ratio. By operating at PdCl(dithiocarbamate)/diamine molar ratio 1:1 chelating diamines yielded the ionic [Pd(dithiocarbamate)(diamine)]Cl species (diamine = en or dap), whereas with long chain diamines species of the type [Pd(dithiocarbamate)(diamine)]nCln (diamine = dab or dah) were obtained, in which each Pd(dithiocarbamate)+ unit binds to the NH2 group of two different molecules, in a network of bridging diamines. At molar ratio 1:0.5, the long chain diamines yielded the binuclear [Pd2Cl2(dithiocarbamate)2(diamine)] complexes (diamine = dab or dah), whereas exchange reactions take place generally in the presence of en or dap. The reaction trend is described on the basis of IR and proton NMR spectra. The new dithiocarbamate complexes were preliminarily tested for their cytotoxicity on human cancer cells.

Item Type:	Article
Keywords:	Palladium complexes; Diamines; Dinuclear complexes; Cytotoxicity;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	7048
Identification Number:	https://doi.org/10.1016/j.ica.2011.07.031
Depositing User:	Diego Montagner
Date Deposited:	23 Mar 2016 10:56
Journal or Publication Title:	Inorganica Chimica Acta
Publisher:	Elsevier
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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