Membrane-Bound Methyltransferase Complex VapA-VipC-VapB Guides Epigenetic Control of Fungal Development


Sarikaya-Bayram, Ozlem and Bayram, Ozgur and Feussner, Kirstin and Kim, Jong-Hwa and Kim, Hee-Soo and Kaever, Alexander and Feussner, Ivo and Chae, Keon-Sang and Han, Dong-Min and Han, Kap-Hoon and Braus, Gerhard H. (2014) Membrane-Bound Methyltransferase Complex VapA-VipC-VapB Guides Epigenetic Control of Fungal Development. Developmental Cell, 29 (4). pp. 406-420. ISSN 1534-5807

[img]
Preview
Download (5MB) | Preview
Official URL: http://dx.doi.org/10.1016/j.devcel.2014.03.020


Share your research

Twitter Facebook LinkedIn GooglePlus Email more...



Add this article to your Mendeley library


Abstract

Epigenetic and transcriptional control of gene expression must be coordinated in response to external signals to promote alternative multicellular developmental programs. The membrane-associated trimeric complex VapA-VipC-VapB controls a signal transduction pathway for fungal differentiation. The VipC-VapB methyltransferases are tethered to the membrane by the FYVE-like zinc finger protein VapA, allowing the nuclear VelB-VeA-LaeA complex to activate transcription for sexual development. Once the release from VapA is triggered, VipCVapB is transported into the nucleus. VipC-VapB physically interacts with VeA and reduces its nuclear import and protein stability, thereby reducing the nuclear VelB-VeA-LaeA complex. Nuclear VapB methyltransferase diminishes the establishment of facultative heterochromatin by decreasing histone 3 lysine 9 trimethylation (H3K9me3). This favors activation of the regulatory genes brlA and abaA, which promote the asexual program. The VapA-VipCVapB methyltransferase pathway combines control of nuclear import and stability of transcription factors with histone modification to foster appropriate differentiation responses.

Item Type: Article
Additional Information: The definitive version of this article is available at DOI: 10.1016/j.devcel.2014.03.020
Keywords: Membrane-Bound; Methyltransferase Complex; VapA-VipC-VapB; Epigenetic Control; Fungal Development;
Academic Unit: Faculty of Science and Engineering > Biology
Item ID: 7182
Depositing User: Ozgur Bayram
Date Deposited: 13 Jul 2016 12:01
Journal or Publication Title: Developmental Cell
Publisher: Elsevier
Refereed: Yes
URI:

Repository Staff Only(login required)

View Item Item control page

Document Downloads

More statistics for this item...