Sarikaya-Bayram, Ozlem and Bayram, Ozgur and Feussner, Kirstin and Kim, Jong-Hwa and Kim, Hee-Soo and Kaever, Alexander and Feussner, Ivo and Chae, Keon-Sang and Han, Dong-Min and Han, Kap-Hoon and Braus, Gerhard H.
(2014)
Membrane-Bound Methyltransferase Complex
VapA-VipC-VapB Guides Epigenetic Control
of Fungal Development.
Developmental Cell, 29 (4).
pp. 406-420.
ISSN 1534-5807
Abstract
Epigenetic and transcriptional control of gene
expression must be coordinated in response to
external signals to promote alternative multicellular
developmental programs. The membrane-associated
trimeric complex VapA-VipC-VapB controls a
signal transduction pathway for fungal differentiation.
The VipC-VapB methyltransferases are tethered
to the membrane by the FYVE-like zinc finger protein
VapA, allowing the nuclear VelB-VeA-LaeA complex
to activate transcription for sexual development.
Once the release from VapA is triggered, VipCVapB
is transported into the nucleus. VipC-VapB
physically interacts with VeA and reduces its nuclear
import and protein stability, thereby reducing the
nuclear VelB-VeA-LaeA complex. Nuclear VapB
methyltransferase diminishes the establishment of
facultative heterochromatin by decreasing histone 3
lysine 9 trimethylation (H3K9me3). This favors activation
of the regulatory genes brlA and abaA, which
promote the asexual program. The VapA-VipCVapB
methyltransferase pathway combines control
of nuclear import and stability of transcription factors
with histone modification to foster appropriate differentiation
responses.
| Item Type: |
Article
|
| Additional Information: |
The definitive version of this article is available at DOI: 10.1016/j.devcel.2014.03.020 |
| Keywords: |
Membrane-Bound; Methyltransferase Complex;
VapA-VipC-VapB; Epigenetic Control; Fungal Development; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
7182 |
| Depositing User: |
Ozgur Bayram
|
| Date Deposited: |
13 Jul 2016 12:01 |
| Journal or Publication Title: |
Developmental Cell |
| Publisher: |
Elsevier |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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