The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation


Mahmoudi, Morteza and Monopoli, Marco P. and Rezaei, Meisam and Lynch, Iseult and Bertoli, Filippo and McManus, Jennifer J. and Dawson, Kenneth A. (2013) The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation. ChemBioChem, 14 (5). pp. 568-572. ISSN 1439-4227

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Abstract

Put your coat on: It is well recognized that the surfaces of nanomaterials in biological media are covered by various biomolecules (e.g., proteins). A) The protein corona creates a shell over different nanomaterials, regardless of their physicochemical properties (e.g., composition and shape), resulting in reduced levels of amyloid beta fibril formation. B) Pristine nanomaterials might have acceleratory effects on the fibrillation of amyloid beta.

Item Type: Article
Keywords: Protein Corona; Nanomaterials; Amyloid Beta Fibrillation;
Academic Unit: Faculty of Science and Engineering > Chemistry
Item ID: 7757
Identification Number: 10.1002/cbic.201300007
Depositing User: Jennifer McManus
Date Deposited: 13 Jan 2017 17:01
Journal or Publication Title: ChemBioChem
Publisher: Wiley
Refereed: Yes
Funders: Higher Education Aithority (HEA), ESF EpitopeMap RNP, EU FP7 Small Collaborative project NeuroNano, Science Foundation Ireland (SFI)
URI:

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