VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism


Bayram, Ozgur and Krappmann, Sven and Ni, Min and Woo Bok, Jin and Helmstaedt, Kerstin and Valerius, Oliver and Braus-Stromeyer, Susanna A. and Kwon, Nak-Jung and Keller, Nancy and Yu, Jae-Hyuk and Braus, Gerhard H. (2008) VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism. Science, 320 (5882). pp. 1504-1506. ISSN 0036-8075

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Abstract

Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In Aspergillus nidulans , light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites.

Item Type: Article
Keywords: VelB/VeA/LaeA; Complex Coordinates; Light Signal; Fungal Development; Secondary Metabolism;
Academic Unit: Faculty of Science and Engineering > Biology
Faculty of Science and Engineering > Research Institutes > Hamilton Institute
Item ID: 8159
Identification Number: 10.1126/science.1155888
Depositing User: Ozgur Bayram
Date Deposited: 12 Apr 2017 15:27
Journal or Publication Title: Science
Publisher: American Association for the Advancement of Science
Refereed: Yes
URI:

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